This natural genetic mutation causes in the rat an absence of the thymus. In the rare cases where vestiges of thymus remain visible, it is generally not functional. This character is accompanied by a deficient immune system due to insufficient production of T lymphocytes cells. The last characteristic controlled by the rnu gene is abnormal growth of hair which ultimately results in bare or almost naked skin sometimes retarded hair grow can be observed. Subsequently the strain obtained is raised as inbred, while taking into account the transmission characteristic of the rnu gene. The ATHYMIC Nude rat is valuable for research because it can serve as a recipient for different autologous and heterologous tumour cell strain implantations, for example in oncology research.
ATHYMIC NUDE Rat
Athymic nude rats: Hsd:RH-Foxn1rnu mutant rats
Henk-Jan Schuurman, Ph. In rats with nude characteristics appeared for the first time in a rat colony at the Rowett Research Institute, Aberdeen, Scotland. At that time nothing was known about the function of the thymus in the immune system, that is, in generation of T thymus-derived lymphocytes in the cell-mediated branch of immunological reactions. Therefore the severe cellular immunodeficiency was not recognized, and no precautions were undertaken to isolate the mutation. Because the mutation reappeared in the s in the same outbred colony May et al. The autosomal recessive mutation is designated rnu. Independently, a second athymic mutant was observed in a colony of random-bred albino rats maintained at Victoria University, Wellington, New Zealand, designated rnu N , nznu , or rnu nz Berridge et al.
When Are Nude Rats Better?
What comes out of your research depends in large part on what goes into your research models. Ensuring your study animals have the most appropriate diet is critical to maintaining consistent, reliable research data. Download growth curve.
Athymic nude rats resemble nude mice in their lack of a normal thymus and functionally mature T cells. They have been useful in the study of mechanisms of tumor growth or graft rejection in immunocompromised hosts since they can accept major histocompatibility complex MHC mismatched organ allografts or xenografts for several months and because a number of tumor cell lines of human and rodent origin grow well in these rats. Injection of a few helper T Th cells from euthymic littermate rats partly restores the pool of mature T cells as well as full immunocompetence to reject organ allografts and has helped to reveal some of the cell interactions necessary for rejection to occur In contrast, immunologically naive athymic nude rats of certain strains, acutely reject allografts consisting of lymphocytes or bone marrow cells, which is due to the presence of alloreactive natural killer cells. These cells can recognize and kill MHC incompatible hematopoietic cells through the recognition of both mismatches within the classical RT1. A and nonclassical RT1.